iGenomics is the first comprehensive mobile genome analysis application, with capabilities to align reads, call variants, and visualize the results entirely on an iOS device. Using high-performance bioinformatics techniques, including FM-index and banded dynamic programming, iGenomics is optimized to run in a mobile environment and has performance comparable to popular desktop genomics software. Furthermore, iGenomics makes DNA alignment and analysis easy and intuitive for the citizen scientist and genomics expert alike.